As pet allergies and immune system concerns become more common, dog owners are increasingly turning to over-the-counter supplements and medications to support their pets’ health. Whether it’s seasonal allergies, food sensitivities, or chronic skin irritation, these conditions can significantly affect your dog’s quality of life. Thankfully, the market offers a wide range of formulations—from chewable tablets and powders to liquid omega oils—designed to alleviate discomfort and bolster the immune system.

In this guide, we’ve compiled the 10 most reviewed allergy and immune support medications for dogs, available through leading online retailers. Each listing provides a concise description, key pros and cons based on user reviews, and current pricing. Our goal is to give you an at-a-glance comparison to help you make an informed decision suited to your dog’s specific needs.

This list covers everything from veterinarian-prescribed solutions to natural, supplement-based alternatives. We’ve remained neutral in our tone, focusing on features that matter: ingredients, ease of use, efficacy, and user-reported results. Whether you’re seeking relief for your dog’s itching or a daily supplement to maintain optimal immune health, the following entries offer a helpful starting point.

FortiFlora by Purina Pro Plan is a veterinary-recommended probiotic supplement designed to support digestive health and bolster immune function in dogs. Each sachet contains a guaranteed amount of Enterococcus faecium to help maintain a healthy balance of intestinal microflora, which can be beneficial for dogs experiencing diarrhea, digestive upset, or stress-related GI issues. The powder is highly palatable and easy to sprinkle over regular meals, making daily use simple. Though primarily aimed at gut health, improved digestion can indirectly aid immune resilience and allergy symptoms. It’s especially helpful during dietary transitions, antibiotic use, or environmental changes.

Pros:

• Proven probiotic strain

• Easy to administer

• Enhances GI health

• Boosts immunity

• Vet-trusted

Cons:

• Pricey

• Requires daily use

• Not allergy-specific

• Single-strain formula

• Some dogs show no change

Price: $30.99 — Buy at

PetHonesty Allergy Support soft chews are formulated to help manage seasonal and environmental allergies in dogs. Made with natural ingredients like colostrum, turmeric, and salmon oil, these chews aim to reduce itching, sneezing, and skin irritation while supporting immune health. The grain-free, salmon-flavored formula appeals to most dogs and contains no artificial preservatives or GMOs. These chews also include probiotics to aid digestion, which may indirectly benefit dogs with allergy-related gut sensitivity. Designed for daily use, the chews provide a holistic approach to allergy support through anti-inflammatory and immune-modulating ingredients.

Pros:

• Natural ingredients
• Palatable flavor
• Skin & coat support
• Immune boost
• Grain-free

Cons:

• Gradual results

• Crumbly texture

• Not for fish-allergic dogs

• Possible soft stool

• Varies by dog

Price: $84.12 — Buy at

Zesty Paws Allergy Immune Bites are soft chews designed to support dogs with seasonal, food, or environmental allergies. These lamb-flavored treats feature ingredients like colostrum, Epicor, and apple cider vinegar to help regulate immune responses and promote skin health. The formula also includes prebiotics and probiotics to aid digestive function, making it a well-rounded supplement for allergy-prone dogs. Free from artificial preservatives, these chews are suitable for dogs of all sizes and breeds. When given daily, they may help reduce itching, sneezing, and hot spots while improving overall immune balance.

Pros:

• Immune-regulating blend

• Digestive support

• Lamb-flavored

• No artificial preservatives

• Suitable for all sizes

Cons:

• Inconsistent results

• Taste may not appeal

• Pricey

• May harden over time

• Daily use required

Price: $58.02  — Buy at

StrellaLab Anti-Itch Allergy Relief Chews are formulated to address itching, hot spots, and inflammation in dogs caused by allergies. These soft chews feature a blend of natural ingredients including omega-3 fatty acids, turmeric, pumpkin powder, and digestive enzymes. Designed for daily use, they support both skin health and immune function while promoting gut balance. The non-drowsy formula is suitable for dogs with mild to moderate allergy symptoms and is free from artificial colors or preservatives. With a chicken flavor most dogs enjoy, it’s a convenient option for pet owners seeking a plant-based, holistic allergy supplement.

Pros:

• Natural ingredients
• Soothes itching
• Skin & coat support
• Digestive aid
• Non-drowsy

Cons:

• May not help severe cases
• Variable texture
• Mixed taste reviews
• Limited research
• Mild GI upset possible

Price: $21.95  — Buy at

Nutri-Vet Pre and Probiotic Soft Chews are designed to promote digestive health and overall wellness in dogs. Each liver-flavored chew contains a combination of prebiotics and five strains of beneficial bacteria to help maintain gut balance, especially during times of stress, dietary changes, or after antibiotic use. These chews indirectly support immune function by improving nutrient absorption and gastrointestinal integrity. They are made in the USA and are ideal for dogs with sensitive stomachs. While not allergy-specific, improved digestive health may help alleviate some allergy-related symptoms in dogs prone to food sensitivities.

Pros:

• Supports digestion
• Five probiotic strains
• Tasty liver flavor
• Affordable
• Immune boost

Cons:

• Not allergy-targeted
• May dry out
• Some dogs uninterested
• Mild effects
• Large dogs need more

Price: $15.29  — Buy at

Finn Allergy & Itch Supplement is a chewable tablet designed to support dogs dealing with seasonal allergies, skin irritation, and itching. Its formula includes bee propolis, quercetin, bromelain, and wild Alaskan salmon oil—ingredients known for their anti-inflammatory and immune-supportive properties. Made with human-grade, non-GMO ingredients, this supplement aims to soothe allergy symptoms while promoting healthy skin and coat. The beef liver flavor appeals to many dogs, and the product is manufactured in the USA under strict quality standards. It’s a convenient daily supplement for dogs prone to itching, paw licking, and inflammation due to allergens.

Pros:

• Anti-inflammatory blend

• Human-grade quality

• Beef liver flavor

• Skin & coat support

• Non-GMO

Cons:

• Pricier option

• Varying effectiveness

• Larger size chew

• May need long-term use

• Mild GI upset possible

Price: $34.00  — Buy at

Native Pet Allergy Chews come in a daily powder form designed to support immune, skin, and gut health in dogs with allergy sensitivities. This vet-formulated blend includes spirulina, colostrum, and postbiotics, aiming to regulate immune response and reduce symptoms like itching and irritation. Free from fillers and artificial ingredients, the formula is grain-free and made with limited, recognizable components. The powder can be easily mixed into meals, making it ideal for dogs that resist chews or tablets. It’s suitable for ongoing use and provides a comprehensive approach to managing allergies through natural and functional nutrition.

Pros:

• Holistic ingredients

• Easy to mix

• Gut & skin support

• No fillers

• Vet-formulated

Cons:

• Powder texture

• Not travel-friendly

• Takes time to work

• Can clump in food

• Some dogs dislike taste

Price: $13.99 (Large) — Buy at

Greenies Hip & Joint Support Supplements are soft, chewable treats formulated to promote joint health in dogs, with added benefits for immune support. Each chew contains glucosamine and chondroitin to maintain healthy cartilage and mobility, alongside antioxidant vitamins that contribute to immune system function. The chicken flavor makes these a tasty and convenient option for daily supplementation. Though primarily focused on joint care, the added nutrients can indirectly support dogs with immune challenges. These low-calorie treats are suitable for regular use and offer a dual-benefit supplement in an easy-to-administer form.

Pros:

• Joint & immune support

• Tasty treat format

• Low calorie

• Easy dosing

• Recognized brand

Cons:

• Not allergy-specific

• Mild immune benefits

• Artificial flavors

• Limited size options

• Lower probiotic content

Price: $14.29  — Buy at

Grizzly Omega Health is a liquid supplement derived from wild-caught Alaskan fish, offering a rich source of EPA and DHA omega-3 fatty acids. Designed to support skin, coat, heart, joint, and immune health, this oil helps reduce inflammation and itching caused by allergies. The easy-to-use pump bottle dispenses the oil directly onto meals, making daily dosing simple. Its high bioavailability ensures effective nutrient absorption, and it contains no artificial additives. While not a complete allergy remedy, it’s a strong complementary supplement for dogs dealing with skin sensitivity or dry, flaky coats.

Pros:

• Rich in omega-3s
• Reduces inflammation
• Easy to dispense
• No additives
• Supports skin & coat

Cons:

• Fishy odor

• Needs refrigeration

• Pump may clog

• Not allergy-specific

• Can stain surfaces

Price: $25.40 — Buy at

The Honest Kitchen Daily Boosters Instant Goat’s Milk is a powdered supplement designed to support digestive and immune health in dogs. Made from dehydrated goat’s milk and enriched with probiotics, it’s ideal for dogs with sensitive stomachs or recovering from illness. The supplement rehydrates quickly into a warm, nourishing drink or can be poured over kibble. It contains no artificial ingredients, preservatives, or fillers, and is made with human-grade standards. Though not allergy-specific, the added probiotics and gentle formulation may help relieve symptoms related to digestive upset or mild food sensitivities.

Pros:

• Digestive support
• Gentle on stomach
• Human-grade
• Easy prep
• Natural ingredients

Cons:

• Short shelf life

• Not allergy-targeted

• Needs mixing

• Some dogs refuse taste

• Small quantity

Price: $16.16 — Buy at